a tool for identifying drug-targetable redox-active disulphides

Protegrin-4

Intramolecular

Cysteine 85 and cysteine 96

A redox-regulated disulphide may form within Protegrin-4 between cysteines 85 and 96.

Details

Redox score ?

86

PDB code

Structure name

solution structure of the cathelin-like domain of protegrins (all amide bonds involving proline residues are in trans conformation)

Structure deposition date

2002-11-07

Thiol separation (Å)

2

Half-sphere exposure sum ?

48

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

85

Residue number B

96

Peptide name

Protegrin-4

Ligandability

Cysteine 85 of Protegrin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Protegrin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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